The Virgin and Child with Saint Anne and the Infant Saint John the Baptist ('The Burlington House Cartoon'), also known as The Leonardo Cartoon, is a full-size preparatory study for a painting. It has, however, never been used to transfer a design onto a panel. The outlines are neither pricked nor incised, and the cartoon must have been preserved in its own right as a finished drawing, although some areas are deliberately left inconclusive or in rough outline.

The pretext for the drawing is likely to have been a commission for a painting given to Leonardo by King Louis XII of France. Leonardo started work on this painting in about 1508. It was unfinished at his death and is now in the Louvre, Paris.