The Virgin Mary is seated on an elaborate throne with the Christ Child. The Child is standing, giving a sign of blessing. Above them, the foreshortened figure of God the Father is dispatching the dove of the Holy Spirit.

This work, together with 'Head of a Tonsured Beardless Saint' and 'Head of a Tonsured Bearded Saint' also in the Collection, are the surviving fragments (now transferred to canvas) from a street tabernacle painted at the Canto de' Carnesecchi, not far from the Piazza Santa Maria Novella, Florence. The two heads of saints are fragments from the sides of the tabernacle.

According to the painter and biographer Giorgio Vasari (1511 - 1574), this was one of Domenico's first works in Florence.