Saints Sebastian and Paul are shown on the left; Saints Lawrence and Benedict (?) are included on the right. On the capital in the centre is a sculpture showing the Sacrifice of Isaac. This picture and its lunette showing the 'Pietà', formed the altarpiece in the Chapel of Saint Anne in S. Frediano, Lucca. The chapel was completed in 1511.
It is clear from the signature on the picture that the altarpiece was finished or almost finished before Francia's death.