This picture is one of the three paintings which formed the predella for Raphael's altarpiece the 'Ansidei Madonna' (dated 1505) in the church of S. Fiorenzo, Perugia. It was placed beneath the image of Saint John in the main altarpiece, who is here shown in the same costume.

Below the Virgin and Child was a depiction of her betrothal and below Saint Nicholas one of his miracles: these panels seem not to have survived.

On loan to the exhibition 'Magister Rafael Iohanis Santis. Gli esordi tra Urbino, Cittá di Castello e Perugia' at the Pinacoteca Comunale, Cittá di Castello, Italy from March to June 2006.