This panel depicts two events from Christ's Passion, each conceived as a subject of visionary contemplation by a saint. In the left background the Deposition of Christ is paired on the right with Saint Francis’s reception of the stigmata – the marks of the wounds which Christ suffered on the cross.

In the foreground, the dead Christ, supported by grieving angels, appears before Saint Jerome who beats his breast with a stone in penitence.

The painting originally formed the right hand side of a diptych, bound in purple velvet with The Adoration of the Shepherds at the left.